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Artikelaktionen

Publikationen aus der Stammzelltransplantation

Neben der Darstellung des Bereichs bei mehreren nationalen und internationalen Kongressen, konnten einige Forschungsergebnisse in den vergangenen Jahren erfolgreich publiziert werden.
Beispielhaft werden nachfolgend einige aktuelle Veröffentlichungen aufgeführt:

  • Kroschinsky, F.; Weise, M.; Illmer, T.; Haenel, M.; Bornhäuser, M.; Hoeffken, G.; Ehninger, G, Schuler, U. Outcome and prognostic features of intensive care unit treatment in patients with hematological malignancies.Intensive Care Med 28 (2002): 1294-1300.
  • Platzbecker,U., Bornhäuser,M., Zimmer,K., Lerche,L., Rutt,C., Ehninger,G., Holig,K. (2005): Second donation of granulocyte-colony-stimulating factor-mobilized peripheral blood progenitor cells: risk factors associated with a low yield of CD34+ cells. Transfusion 45, 11-15.
  • Bornhäuser,M., Eger,L., Oelschlaegel,U., Auffermann-Gretzinger,S., Kiani,A., Schetelig,J., Illmer,T., Schaich,M., Corbeil,D., Thiede,C., Ehninger,G. (2005):
    Rapid reconstitution of dendritic cells after allogeneic transplantation of CD133+ selected hematopoietic stem cells. Leukemia 19, 161-165.
  • Platzbecker,U., Thiede,C., Fussel,M., Geissler,G., Illmer,T., Mohr,B., Hanel,M., Mahlberg,R., Krumpelmann,U., Weissinger,F., Schaich,M., Theuser,C., Ehninger,G., Bornhäuser,M. Reduced intensity conditioning allows for up-front allogeneic hematopoietic stem cell transplantation after cytoreductive induction therapy in newly-diagnosed high-risk acute myeloid leukemia. Leukemia 20, 707-714 (2006)
  • Einsele,H., Reusser,P., Bornhäuser,M., Kalhs,P., Ehninger,G., Hebart,H., Chalandon,Y., Kroger,N., Hertenstein,B., Rohde,F. Oral valganciclovir leads to higher exposure to ganciclovir than intravenous ganciclovir in patients following allogeneic stem cell transplantation. Blood 107, 3002-3008 (2006)
  • Rieger,K., Loddenkemper,C., Maul,J., Fietz,T., Wolff,D., Terpe,H., Steiner,B., Berg,E., Miehlke,S., Bornhäuser,M., Schneider,T., Zeitz,M., Stein,H., Thiel,E., Duchmann,R., Uharek,L. Mucosal FOXP3+ regulatory T cells are numerically deficient in acute and chronic GvHD. Blood 107, 1717-1723 (2006)
  • Babatz,J., Rollig,C., Lobel,B., Folprecht,G., Haack,M., Gunther,H., Kohne,C.H., Ehninger,G., Schmitz,M., Bornhäuser,M. Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. Cancer Immunol. Immunother. 55, 268-276 (2006)
  • Bornhäuser,M., Kroger,N., Schwerdtfeger,R., Schafer-Eckart,K., Sayer,H.G., Scheid,C., Stelljes,M., Kienast,J., Mundhenk,P., Fruehauf,S., Kiehl,M.G., Wandt,H., Theuser,C., Ehninger,G., Zander,A.R. Allogeneic haematopoietic cell transplantation for chronic myelogenous leukaemia in the era of imatinib: a retrospective multicentre study. Eur. J. Haematol. 76, 9-17 (2006)
  • Kiehl,M.G., Kraut,L., Schwerdtfeger,R., Hertenstein,B., Remberger,M., Kroeger,N., Stelljes,M., Bornhäuser,M., Martin,H., Scheid,C., Ganser,A., Zander,A.R., Kienast,J., Ehninger,G., Hoelzer,D., Diehl,V., Fauser,A.A., Ringden,O. (2004): Outcome of allogeneic hematopoietic stem-cell transplantation in adult patients with acute lymphoblastic leukemia: no difference in related compared with unrelated transplant in first complete remission. J. Clin. Oncol. 22, 2816-2825.
  • Oswald,J., Boxberger,S., Jorgensen,B., Feldmann,S., Ehninger,G., Bornhäuser,M., Werner,C. (2004): Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells 22, 377-384.
  • Bornhäuser,M., Schwerdtfeger,R., Martin,H., Frank,K.H., Theuser,C., Ehninger,G. (2004): Role of KIR ligand incompatibility in hematopoietic stem cell transplantation using unrelated donors. Blood 103, 2860-2861.
  • Bornhäuser,M., Klenk,U., Rollig,C., Haack,M., Babatz,J., Koch,O., Baretton,G., Ehninger,G. (2004): Mixed response after allogeneic haemopoietic-cell transplantation for metastatic renal-cell carcinoma. Lancet Oncol. 5, 191-192.
  • Thiede,C., Bornhäuser,M., Ehninger,G. (2004): Evaluation of STR informativity for chimerism testing--comparative analysis of 27 STR systems in 203 matched related donor recipient pairs. Leukemia 18, 248-254.
  • Babatz,J., Rollig,C., Oelschlagel,U., Zhao,S., Ehninger,G., Schmitz,M., Bornhäuser,M. (2003): Large-scale immunomagnetic selection of CD14+ monocytes to generate dendritic cells for cancer immunotherapy: a phase I study. J. Hematother. Stem Cell Res. 12, 515-523.
  • Schetelig,J., Thiede,C., Bornhäuser,M., Schwerdtfeger,R., Kiehl,M., Beyer,J., Sayer,H.G., Kroger,N., Hensel,M., Scheffold,C., Held,T.K., Hoffken,K., Ho,A.D., Kienast,J., Neubauer,A., Zander,A.R., Fauser,A.A., Ehninger,G., Siegert,W. (2003): Evidence of a graft-versus-leukemia effect in chronic lymphocytic leukemia after reduced-intensity conditioning and allogeneic stem-cell transplantation: the Cooperative German Transplant Study Group. J. Clin. Oncol. 21, 2747-2753.
  • Bornhäuser,M., Storer,B., Slattery,J.T., Appelbaum,F.R., Deeg,H.J., Hansen,J., Martin,P.J., McDonald,G.B., Nichols,W.G., Radich,J., Woolfrey,A., Jenke,A., Schleyer,E., Thiede,C., Ehninger,G., Anasetti,C. (2003): Conditioning with fludarabine and targeted busulfan for transplantation of allogeneic hematopoietic stem cells. Blood 102, 820-826.
  • Rollig,C., Babatz,J., Wagner,I., Maiwald,A., Schwarze,V., Ehninger,G., Bornhäuser,M. (2002): Thawing of cryopreserved mobilized peripheral blood--comparison between waterbath and dry warming device. Cytotherapy. 4, 551-555.
  • Arnold,R., Massenkeil,G., Bornhäuser,M., Ehninger,G., Beelen,D.W., Fauser,A.A., Hegenbart,U., Hertenstein,B., Ho,A.D., Knauf,W., Kolb,H.J., Kolbe,K., Sayer,H.G., Schwerdtfeger,R., Wandt,H., Hoelzer,D. (2002): Nonmyeloablative stem cell transplantation in adults with high-risk ALL may be effective in early but not in advanced disease. Leukemia 16, 2423-2428.
  • Schmitz,M., Bornhäuser,M., Ockert,D., Rieber,E.P. (2002): Cancer immunotherapy: novel strategies and clinical experiences. Trends Immunol. 23, 428-429.
  • Bornhäuser,M., Platzbecker,U., Theuser,C., Holig,K., Ehninger,G. (2002): CD34+-enriched peripheral blood progenitor cells from unrelated donors for allografting of adult patients: high risk of graft failure, infection and relapse despite donor lymphocyte add-back. Br. J. Haematol. 118, 1095-1103.
  • Schmitz,M., Zhao,S., Schakel,K., Bornhäuser,M., Ockert,D., Rieber,E.P. (2002): Native human blood dendritic cells as potent effectors in antibody-dependent cellular cytotoxicity. Blood 100, 1502-1504.
  • Thiede,C., Steudel,C., Mohr,B., Schaich,M., Schakel,U., Platzbecker,U., Wermke,M., Bornhäuser,M., Ritter,M., Neubauer,A., Ehninger,G., Illmer,T. (2002): Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood 99, 4326-4335.
  • Bornhäuser,M., Kiehl,M., Siegert,W., Schetelig,J., Hertenstein,B., Martin,H., Schwerdtfeger,R., Sayer,H.G., Runde,V., Kroger,N., Theuser,C., Ehninger,G. (2001): Dose-reduced conditioning for allografting in 44 patients with chronic myeloid leukaemia: a retrospective analysis. Br. J. Haematol. 115, 119-124.
  • Bornhäuser,M., Thiede,C., Platzbecker,U., Jenke,A., Helwig,A., Plettig,R., Freiberg-Richter,J., Rollig,C., Geissler,G., Lutterbeck,K., Oelschlagel,U., Ehninger,G. (2001): Dose-reduced conditioning and allogeneic hematopoietic stem cell transplantation from unrelated donors in 42 patients. Clin. Cancer Res. 7, 2254-2262.
  • Thiede,C., Bornhäuser,M., Oelschlagel,U., Brendel,C., Leo,R., Daxberger,H., Mohr,B., Florek,M., Kroschinsky,F., Geissler,G., Naumann,R., Ritter,M., Prange-Krex,G., Lion,T., Neubauer,A., Ehninger,G. (2001): Sequential monitoring of chimerism and detection of minimal residual disease after allogeneic blood stem cell transplantation (BSCT) using multiplex PCR amplification of short tandem repeat-markers. Leukemia 15, 293-302.
  • Mohr,B., Bornhäuser,M., Thiede,C., Schakel,U., Schaich,M., Illmer,T., Pascheberg,U., Ehninger,G. (2000): Comparison of spectral karyotyping and conventional cytogenetics in 39 patients with acute myeloid leukemia and myelodysplastic syndrome. Leukemia 14, 1031-1038.
  • Kohler,T., Plettig,R., Wetzstein,W., Schmitz,M., Ritter,M., Mohr,B., Schaekel,U., Ehninger,G., Bornhäuser,M. (2000): Cytokine-driven differentiation of blasts from patients with acute myelogenous and lymphoblastic leukemia into dendritic cells. Stem Cells 18, 139-147.
  • Brendel,C., Mohr,B., Schimmelpfennig,C., Muller,J., Bornhäuser,M., Schmidt,M., Ritter,M., Ehninger,G., Neubauer,A. (1999): Detection of cytogenetic aberrations both in CD90 (Thy-1)-positive and (Thy-1)-negative stem cell (CD34) subfractions of patients with acute and chronic myeloid leukemias. Leukemia 13, 1770-1775.
  • Bornhäuser,M., Thiede,C., Brendel,C., Geissler,G., Oelschlagel,U., Neubauer,A., Ehninger,G. (1999): Stable engraftment after megadose blood stem cell transplantation across the HLA barrier: the case for natural killer cells as graft-facilitating cells. Transplantation 68, 87-88.
  • Ringden,O., Remberger,M., Runde,V., Bornhäuser,M., Blau,I.W., Basara,N., Holig,K., Beelen,D.W., Hagglund,H., Basu,O., Ehninger,G., Fauser,A.A. (1999): Peripheral blood stem cell transplantation from unrelated donors: a comparison with marrow transplantation. Blood 94, 455-464.
  • Kohler,T., Plettig,R., Wetzstein,W., Schaffer,B., Ordemann,R., Nagels,H.O., Ehninger,G., Bornhäuser,M. (1999): Defining optimum conditions for the ex vivo expansion of human umbilical cord blood cells. Influences of progenitor enrichment, interference with feeder layers, early-acting cytokines and agitation of culture vessels. Stem Cells 17, 19-24.
  • Bornhäuser,M., Schuler,U., Porksen,G., Naumann,R., Geissler,G., Thiede,C., Schwerdtfeger,R., Ehninger,G., Thiede,H.M. (1999): Mycophenolate mofetil and cyclosporine as graft-versus-host disease prophylaxis after allogeneic blood stem cell transplantation. Transplantation 67, 499-504.
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